Sialyl lewis-x
Websialyl-Lewis X: A tetrasaccharide carbohydrate antigen that attaches to O-glycans on cell surfaces. Physiology The sialyl-Lewis X determinant, E-selectin ligand carbohydrate, is constitutively expressed on granulocytes and monocytes, and mediates their extravasation during inflammation; resting Th2 and B cells do not express sialyl-Lewis X, ...
Sialyl lewis-x
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WebFeb 27, 2024 · The Sialyl Lewis A antigen, or CA 19-9, is the prototype serum biomarker for adenocarcinoma of the pancreas. Despite extensive clinical study of CA 19-9 in gastrointestinal malignancies ... WebOct 21, 2024 · The impact of glycosylation on cell behavior largely depends on the terminal portions of glycoconjugates. Examples of terminal structures include α2,3- and α2,6-linked sialic acids, polysialic acid, the AB0 blood group, and other fucosylated structures such as the sialyl Lewis x (sLe x) and the sialyl Lewis a (sLe a) antigens [1,2,3].
WebJun 11, 2004 · Divergent syntheses of sulfated sialyl Lewis X oligosaccharides corresponding to the core 1 and core 6 branches of the l-selectin ligand are reported. These synthetic targets incorporate a selectively protected serine residue at the reducing terminus, providing a functional handle for further conjugation. WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the monoclonal antibody CHO-131.This antibody selects s-Le x antigen at points of branching in which the GlcNAc residue of s-Le x is coupled in a β-(1,6) linkage. 60 At N-linked glycosylation sites, s-Le x is conjugated to the glycan matrix through a -GlcNAc-β-(1,6)-Man- linkage and …
WebApr 1, 1995 · An efficient synthesis of sialyl Lewis X (sLex) glycolipid as a potent selectin blocker is described. 2-(Tetradecyl)hexadecanol which functions as an artificial ceramide, was glycosylated with phenyl … Expand. 4. Save. Alert. Synthesis of the 3'-C-carboxymethyl Lewis X derivative: A novel selectin blocker. WebAug 20, 2015 · Aberrant glycosylation in cancer frequently involves an increase in sialyl Lewis x (SLe x) and SLe a (Ref. 41) antigens, as well as an increase in terminal α2,6-sialylated structures, both in ...
WebSialyl-Lewis x (s-Le x)-bearing species have been selected from plasma with the …
WebJan 18, 2024 · Among the best described ligands for the selectins are derivatives of the … grants for nhs projectsWebThe carbohydrate structure sialyl-Lewis X (SLex) can function as a ligand for E-selectin, … chipmong portal loginWebAug 15, 1995 · After removal of sialic acids, most of the mucins rich in sialyl-Lewis(a) and sialyl-Lewis(x) oligosaccharides no longer bound to a DEAE-cellulose column at pH 8.0. These results indicate that at least part of the sialyl-Lewis(a) and sialyl-Lewis(x) in SW1990 cells is associated with the MUC1 polypeptide. chip mong portalWebSialyl-Lewis X C31H52N2O23 CID 643990 - structure, chemical names, physical and … grants for ngo\\u0027s and orphanages in africaWebJan 16, 2014 · Using these methods, sialyl Lewis A or Lewis X moieties were found to be … chip mong online shoppingWebJun 8, 2010 · For example, sialyl-Lewis x (sLe x) antigens are the ligands for selectins and are involved in the recruitment of leukocytes to lymphoid tissues and inflammation sites . Glycan structures depend on the cell type, developmental stage and cell differentiation, and are modified in many pathologic states including cancers. chip mong land co. ltdWebNov 4, 2024 · Trinchera, M., Aronica, A. & Dall’Olio, F. Selectin ligands sialyl-lewis a and sialyl-lewis x in gastrointestinal cancers. Biology 6 , 16 (2024). Article PubMed Central Google Scholar chipmong portal