WebMyeloma cast nephropathy is an obstructing disorder of renal tubules, caused by precipitation of Bence Jones proteins. Myeloma-like cast nephropathy (MLCN) has … WebIn order to confirm the additional adverse effects of KU55933 on cisplatin-induced DNA damage and to elucidate the For all groups, data are means ± SEM, *p < 0.05 vs control, # p < 0.05 vs ...
Evaluation of acute and chronic nephrotoxicity in patients
WebApr 12, 2024 · In recent years, the onco-nephrology field has acquired a relevant role in internal medicine due to the growing number of cases of renal dysfunction that have been observed in cancer patients. This clinical complication can be induced by the tumor itself (for example, due to obstructive phenomena affecting the excretory tract or by neoplastic … WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe … oleander provence
Cisplatin Nephrotoxicity: A Review - Neil Kurtzman
WebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... WebOct 6, 2016 · Cisplatin [Cis-diamminedichloroplatinum (II)] is the most nephrotoxic chemotherapeutic drug, discovered over four decades ago. Nephrotoxicity is the major side effect that limits the dose of cisplatin that can be safely administered, and it is a clinical problem in cancer patients who receive cisplatin combination chemotherapy. WebAug 1, 2007 · Cisplatin nephrotoxicity primarily causes tubulo-interstitial lesions. In animal models cisplatin damages the proximal tubules, specifically the S3 segment of the outer medullary stripe. Mitochondrial swelling and nuclear pallor occur in the distal nephron. The glomerulus has no obvious morphologic changes.49., 56., 59. oleander psychonauts