Cisplatin induced ros
WebMar 20, 2024 · Higher expression of glutathione reductase accompanied by lower levels of endogenous reactive oxygen species (ROS) contributes to the cisplatin-resistance ( Zhu et al., 2024 ). Metallothionein Platinum … WebNov 19, 2013 · Cisplatin treatment induced a lower ROS response and toxicity in TFAM +/-cells compared to the isogenic WT cells (Figure 5C-D), indicating that mitochondrial …
Cisplatin induced ros
Did you know?
WebSep 14, 2024 · Cisplatin is one of the largest classes of valuable clinical chemotherapeutic agents against various malnancies. 1, 2 However, the ototoxicity induced by cisplatin is one of the most serious adverse effects of cisplatin administration, which results in irreversible, progressive, bilateral and accumulative hearing impairment, thereby limiting … WebWe found that cisplatin treatment led to SGN damage, in which reactive oxygen species (ROS) generation increased, PINK1 expression decreased, BAD accumulation on mitochondria raised and mitochondrial apoptotic pathway activated. Conversely, we demonstrated that PF pre-treatment obviously mitigated cisplatin-induced SGN damage.
WebCisplatin helps in the treatment of various types of cancers in the body like such as ovarian, lung, head and neck, testicular and bladder. 5 Cisplatin is efficient in use against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. WebSep 19, 2024 · Cisplatin destroys intracellular antioxidants, disrupts the redox balance, and interferes with the mitochondrial respiratory chain, leading to elevated ROS [ 7 ]. Many studies have reported that excess ROS induce the JNK/P38 MAPK signaling pathway and activate caspase-dependent apoptosis [ 8, 9 ].
WebNov 19, 2013 · Cisplatin treatment induced a lower ROS response and toxicity in TFAM +/-cells compared to the isogenic WT cells (Figure 5C-D), indicating that … WebNeurotoxicity is an obvious adverse effect in Patients encountering a complete course of chemotherapy. The present work is conducted to evaluate the neuroprotective effect of Ginkgo biloba (Ginkgo) against the neurotoxicity induced by Cisplatin (Cis) in rats. Forty male Wistar albino rats were arranged into four groups: (1) Control group, rats were …
WebJan 15, 2024 · Cisplatin is a chemotherapeutic agent widely used to treat various malignancies, and its application is greatly limited due to its nephrotoxicity, including its onset of acute kidney injury (AKI) [ 1 ]. Undoubtedly, effective drugs to prevent cisplatin-induced AKI (Cis-AKI) in clinical practice are in urgent demand.
WebSep 19, 2024 · Cisplatin destroys intracellular antioxidants, disrupts the redox balance, and interferes with the mitochondrial respiratory chain, leading to elevated ROS [ 7 ]. Many … ear pain after hitting headWebNov 19, 2013 · Cisplatin exposure results in intracellular ROS increase in normal cells [21–23] and treatment with antioxidants ameliorates the toxic effects of cisplatin on several organs [24–27], suggesting an involvement of oxidative stress in the pathogenesis of cisplatin-induced dose-limiting toxicities. However, little is known about the mechanism ... ear pain after flying remedyWebFurthermore, the levels of reactive oxygen species (ROS) were enhanced after carvacrol exposure and cotreatment with NAC, the ROS scavenger, decreased the levels of cleaved PARP and caspase 3, suggesting the involvement of ROS in carvacrol-induced apoptosis. ... indicating that cisplatin-induced ER stress protects cell from apoptosis in these ... ct3012h1WebA novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial ROS-mediated ferroptosis A novel 3-phenylglutaric acid derivative (84-B10) alleviates cisplatin-induced acute kidney injury by inhibiting mitochondrial ROS-mediated ferroptosis ct301WebCisplatin-induced early-onset ototoxicity is linked to hearing loss. The mechanism by which cisplatin causes ototoxicity remains unclear. The purpose of this study was to identify the involvement of receptor-interacting protein kinase (RIP)3-dependent necroptosis in … ct 300w solar panelsWebCisplatin is also sometimes used to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), lung cancer, cancer of the … ear pain after sleepingWebMoreover, the potential chemo-sensitizing effects of DSF on ALDH-associated cisplatin-resistant ovarian cancer stem cells were also investigated and shown that in contrast to its high resistance to cisplatin, the cisplatin-resistant cells remain very sensitive to DSF-induced cytotoxicity (apoptosis and necrosis: cisplatin-resistant cells vs ... ear pain after head trauma